|
KMID : 0613820110210020202
|
|
Journal of Life Science
2011 Volume.21 No. 2 p.202 ~ p.210
|
|
|
Expressional Regulation of Replication Factor C in Adipocyte Differentiation
|
|
Cho Hyun-Kook
Kim Hye-Young
Yu Hyun-Jeong
Cheong Jae-Hun
|
|
|
Abstract
|
|
|
|
Adipocyte differentiation is an ordered multistep process requiring the sequential activation of several groups of adipogenic transcription factors, including CCAAT/enhancer-binding protein- and peroxisome proliferator-activated receptor-, and coactivators. In previous reports, we identified that replication factor C 140 (RFC140) protein played a critical role in regulating adipocyte differentiation as a coactivator. Here, we show expressional regulation of RFC140 and small RFC subunit, RFC38, following characterization of gene promoter of RFC140 and RFC38. In addition, RFC140 increases PPAR-mediated gene activation, resulting from direct protein-protein interaction of RFC140 and PPAR. Taken together, these findings demonstrate that the regulated expression of RFC140 and RFC38 by specific adipocyte transcription factors is required for the adipocyte differentiation process.
|
|
|
KEYWORD
|
|
|
Replication factor C, adipocyte differenation, C/EBP, ATF2, PPAR
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|